The sublingual mood booster
Sam-E & Methylation
One of Slenderella Bliss' main ingredients is SAMe, which stands for S-adenosyl-L-methionine. SAMe is a compound produced by the liver and used throughout the body in a chemical process called methylation. Methylation, essential to many chemical reactions in the body, is one of the last steps in the production of serotonin, dopamine and norepinephrine.
Liver Health and
Slenderella Bliss delivers methyl groups, which are needed for the synthesis of neurotransmitters, proteins, nucleic acids, and phospholipids. It supports glutathione production, liver health, joint comfort, and a healthy mood. The other main ingredient is TMG ultimately supports cardiovascular and neurological health, as well as normal cell-life regulation.
become a methylator
SAMe is the “universal” methyl donor for biochemical reactions
throughout the body. This methyl transfer, or “transmethylation,” is critical to reactions
involving proteins, phospholipids, DNA, RNA, creatine, hormones, development of
cell membranes, degradation of histamine, and formation of norepinephrine and
dopamine. Eighty-five percent of transmethylation takes place in the liver, and
healthy SAMe levels appear to be essential to liver health and function.
Slenderella's SAM-e contains a minimum of 70% of the SS isomer of SAMe, the form the body can use most readily. This relatively high concentration from Gnosis’ Adomix® not only makes SAM-e particularly bioavailable but also cost-effective. Each
capsule is sealed in a nitrogen-purged blister pack to maximize protection from the
Antioxidant and Liver Support
SAMe is considered to be “critical” for synthesis of glutathione, a principal component of antioxidant and detoxification systems in the body. Following donation of a methyl group, SAMe is converted to S-adenosylhomocysteine (SAH). This biochemical reaction promotes the transsulfuration pathway in
the liver that generates glutathione. Further metabolism of SAH involves trimethylglycine
(TMG), also known as betaine anhydrous. TMG plays an important role in maintaining a
healthy SAMe:SAH ratio in the liver.
Trimethylglycine is a naturally occurring compound (glycine attached to three
methyl groups) that is found in naturally and can be produced in the body from the precursor choline. TMG is thought to protect liver cells, support
homocysteine metabolism and cardiovascular health, and may also support a healthy mood due to its role in SAMe metabolism. When TMG donates a single methyl group, it is converted to dimethylglycine (DMG), which is capable of donating two methyl groups. TMG is thought to stimulate activity of the enzyme betaine-homocysteine methyltransferase (BHMT). BHMT, found in abundance in a healthy liver, is used
by TMG to donate a methyl group to homocysteine. Once TMG adds a methyl group to homocysteine to produce methionine, the methionine can then be converted to SAMe. A randomized, double-blind, crossover study of healthy volunteers suggested that TMG supplementation (at doses of 3 g and 6 g/d) has a dose-dependent effect on serum TMG
levels and a significantly positive effect on maintaining healthy homocysteine levels.
Together, SAMe and TMG provide an abundant source of methyl groups and ultimately
support a wide variety of biochemical reactions in the body.
*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.*